Proje Geliştirme ve
Koordinasyon Birimi

2016-11-16 Ukraine: How to Tackle the Childhood Obesity Epidemic


 

How to Tackle the Childhood Obesity Epidemic


Description of the project offered: 
SFS-39-2017: How to tackle the childhood obesity epidemic?
Early diagnosis of metabolic syndrome in children and adolescents by the estimation of adipokines
The main aim of this research is to increase effectiveness in early diagnosis of metabolic syndrome and its complications in children by the estimation of its metabolic preclinical signs.
In the early diagnosis of metabolic syndrome in children identification of preclinical signs and biomarkers are necessary. We can reveal the possibility of early diagnosis of metabolic syndrome by the hyperleptinemia and leptin resistance.
We have estimated that the concentration of leptin in the blood [18,6 (10,3−38,5) pmo/ml; p=0,002] and the frequency of hyperleptinemia diagnosis (86,8%; p=0,002) in children with metabolic syndrome was higher than in children with the normal body mass. Received data prove early formation of hyperleptinemia and leptin resistance in children and possibility of its usage in preclinical diagnosis. 
There has also been revealed a direct correlation link between leptin in the blood and metabolic syndrome criteria: parameters of anthropometric criterion (body mass index, circumference of the waist), systolic and diastolic blood pressure and inderect correlation link with high density cholesterol, that prove the influence of hyperleptinemia on abdominal obesity and proatherogenic dislipidemia formation, blood pressure increase.
We revealed that hyperleptinemia in children is characterized by increase on 4,8% (h=0,001) circumference of the waist, on 10,2% (p=0,001) circumference of the waist/height ratio, insulin in the blood on 32,8% (h=0,001), low density cholesterol on 17,4% (p=0,026), tryglicerides 1,3 times (p=0,029). 
The actual approach is to study other preclinical signs of metabolic syndrome, its diagnostic and prognostic biomarkers, which reveal the early stages of metabolic syndrome development and permit its early diagnosis. Children with metabolic syndrome have adiposopathy, discharge of the endocrine function of adipose tissue. It is also necessary to study hormone active substances which are synthetized by adipocytes: apodectine, dipoapeline, visfatine, obestatine, preadipocite factor-1, nesfatine, chemerine.
We think that early diagnosis of metabolic syndrome consists of identification of adipokines by the overpoint ranges of them that are determined by the Wald method. It’s important to study the role of adipokines in the development of metabolic syndrome criteria: obesity, hyperglycemia, hypertrigliceridemia, high density cholesterol, systolic and diastolic blood pressure and there links. 
Our approach to solving the problem of early diagnosis of metabolic syndrome is to examine the children with overweight (body mass index more than 90-th percentile), general obesity ( body mass index more than 95-th percentile), abdominal obesity (circumference of the waist more than 90-th percentile) and to determine adipokines apodectine, dipoapeline, visfatine, obestatine, preadipocite factor-1, nesfatine, chemerine in the blood with complex clinical examination of the children: estimation of carbohydrate metabolism (glucose, insulin, calculation of HOMA-IR and Caro, tolerance test to glucose, HbA1c), lipid metabolism (cholesterol, high density cholesterol, low density cholesterol, non-high density cholesterol) in children with metabolic syndrome and obesity, ultrasound examination with estimation of left ventricular myocardial mass, left ventricular myocardial mass index on height in 2,7 degree, stroke volume and ejection fraction, calculation of glomerular filtration rate, identification of microalbuminuria and microproteinuria.
Project proposer:   Natalia Gromnatska ()
Partner role:  Project participant 
Partner organisation:  Consultancy
Call for proposal title:  N/A 


Description of the collaboration sought: 
For the research work are necessary:
1. Practitioners that have knowledge in metabolic syndrome diagnosis and prevention; 
2. Laboratory assistant for definition (determination) of adipokines by immunoferment method, lipid metabolism by ferment method, glucose by glucoseoxidant method, insulin by immunopherment method, creatinine by biochemical method, microalbuminuria by immunoferment method;
3. Specialist of ultrasound examination. 
Expertise sought: Medicine. Health, 
Roles sought: Project coordinator, Project participant, 
Organisation types sought: Research, Education,