Proje Geliştirme ve
Koordinasyon Birimi

2015-12-31 United Kingdom: Smart Materials: Capture and Detection of Biologicals (Cells, Proteins and Viruses)


 Smart Materials: Capture and Detection of Biologicals (Cells, Proteins and Viruses)

Description of the project offered: 
Reddy’s team is developing hydrogel-based molecularly imprinted polymers (HydroMIPs) for the memory imprinting of proteins and for protein biosensor development. The molecular imprint remains as a memory effect in the gel after the protein is removed, and the remaining cavity exhibits highly selective rebinding of said protein. The possibilities for this HydroMIP technology are vast including uses in bio-sample clean-up or selective extraction, replacement of biological antibodies in immunoassays and biosensors for medicine. Molecularly imprinted polymers (MIPs) have become an important tool in the preparation of artificial and robust recognition materials that are capable of mimicking natural systems. When compared to natural recognition products such as antibodies, MIPs offer advantages such as durability, specificity and ease of mass production, that have previously not been offered by alternative techniques. To date, MIPs have been widely used in a number of applications including chromatographic applications, solid phase extraction, catalysis and various sensor strategies.

Traditional MIPs only demonstrate their selectivity when they rebind template in the organic solvent in which they were synthesised. These methods are therefore unsuitable for imprinting of biomolecules such as biological species as they are denatured under such organic solvent conditions. Our hydrogels can offer a compromise between the polymerisation required for cavity formation and the need to keep protein structural integrity during imprinting. 

Our proposed research considers a new approach to the use of HydroMIPS, that of harnessing them as surfaces for selectively trapping and detecting biologicals such as proteins, viruses and cells for diagnostic applications and potentially treating disease. The materials have further potential applications in medicine, food and the environment.
Project proposer:   Sub Reddy (United Kingdom)
Partner role:  Project participant 
Partner organisation:  Research
Call for proposal title:  N/A 

Description of the collaboration sought: 
We are looking for partners with complimentary expertise in sensor development (and miniaturization); integration of receptors to sensor surfaces and biomedical scientists for development of novel bio-materials for biorecognition and biomimicry. 
Expertise sought: Veterinary and animal sciences, Medical biotechnology, Life sciences, Biotechnology, Medicine. Health, Nanotechnology and Nanosciences, Materials technology, Electronics. Microelectronics, 
Roles sought: Project coordinator, Project participant, 
Organisation types sought: 
Countries sought: Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom, Albania, Bosnia and Herzegovina, Croatia, Iceland, Israel, Liechtenstein, Macedonia, the former Yugoslav Republic of, Montenegro, Norway, Serbia, Switzerland, Turkey, Brazil,