Proje Geliştirme ve
Koordinasyon Birimi

2015-12-25 Ukraine: High Throughput DNA Sequencing for Large-Scale Research of BRCA1/2 Gene Mutations in Cancer Patients and Their Relatives in Eastern Europe


High Throughput DNA Sequencing for Large-Scale Research of BRCA1/2 Gene Mutations in Cancer Patients and Their Relatives in Eastern Europe

Description of the project offered: 
The incidence of cancer associated with mutations in BRCA 1/2 genes, namely breast (BC), ovarian (OC) and prostate cancers (PC), every year is rapidly growing. Study of BRCA 1/2 gene mutation variant, their prevalence, inheritance, association with clinical characteristics for early diagnosis and diseases prevention is an important and perspective task of modern oncology. The spectrum and frequency of inherited BRCA mutations in patients with cancers in majority of European countries well established. Currently, in Eastern Europe large-scale research of BRCA 1/2 gene mutations has not been carried out, there are only sporadic researches in the small cohorts. Analysis of mutations diversity in BRCA 1/2 genes among the population of Eastern Europe is also promising in terms of understanding of epidemiological dissemination and evolutionary origin and consolidation of relationship among ethnic groups in the region of Europe. Ukraine has conducted initial researches to identify the most common known mutations in BRCA 1/2 genes in BC and OC and found that different regions of the country has its own types of mutations. Also, we assume that in the population on such a large area new, hitherto unexplored mutations in these genes can be identify that may have their own contribution in the development and progression of the disease.
Objectives of the project:
• to collect biomaterial from patients with BC, OC, PC from Ukraine, Poland and Belarus and create a biobank; 
• sequencing of BRCA 1/2 genes in tumor cells for detection of generative and somatic mutations
• screening of cancer patients and their relatives to identify mutations in BRCA 1/2 (blood samples)
• to analyze healthy donors from certain ethnic regions to identify the prevalence and frequency of mutation variants in BRCA1/2 genes.
Project proposer:   Natalia Khranovska (Ukraine)
Partner role:  Project participant 
Partner organisation:  Research
Call for proposal title:  Integrating and opening research infrastructures of European interest 
Call for proposal identifier:  H2020-INFRAIA-2016-2017

Description of the collaboration sought: 
We are looking for advanced research infrastructure, scientific communities, industries which offer their high throughput DNA sequencing technology complex for joint research activities. 
Expertise sought: Scientific research, Coordination. Cooperation, Innovation. Technology transfer, Education. Training, Social aspects, Medical biotechnology, Life sciences, Biotechnology, Medicine. Health, 
Roles sought: Project participant, 
Organisation types sought: Technology transfer, Small or medium-sized enterprise (SME), Non-governmental organisation (NGO), Research, 
Countries sought: Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom, Austria, Belarus, 

Call for proposal specific information
The referenced call for proposals has no specific fields defined.