Proje Geliştirme ve
Koordinasyon Birimi

2015-12-06 Ukraine: Antibiotic Resistance Accompanied with Recurrent Urinary Tract Infection in Children: Biofilm Formation


 

Antibiotic Resistance Accompanied with Recurrent Urinary Tract Infection in Children: Biofilm Formation

Description of the project offered: 
Antibiotic resistance is a question of great importance in medicine as it concerns both medical and social problems. First of all the originating and spreading of resisting microorganisms, for instance in hospitals, results in hospitalization period prolongation, which means economical loses, and what is more important, in lethality growth. The social importance of antimicrobial resistance is also defined by the resistant virus strains spreading in out-hospital medium and it, in its turn, results in reducing of banal infections therapy effectiveness and the necessity of more expensive medicines.
Nowadays the growth of antibiotic resistance is connected with the possibility of the development of the certain bacteria life process namely the biofilm formation. This lifeform increases the microorganisms’ antibiotic resistance and it results in the latent infection clinical course and belated therapy.
Nowadays 65% of all infectious deceases are considered to be due to microorganisms existing in the form of biofilms. These bacteria biofilms can be made up of bacteria of one or more kinds and they consist of both active functioning and non-cultivated forms or forms at rest. The urinary tract infections (UTI) belong to the most common diseases connected with the biofilms presence.
The current investigation main objective is the study of the children’s uropathogenic microflora and its ability to form biofilms with the relapsing UTI.
Goal: investigation of the uropathogenic microflora peculiarities and its ability to form biofilms in case of the children’s relapsing urine track system infection.
Objectives:
1. to study the frequency of the children’s relapsing urine track system infection
2.to study the uropathogenic agents spectrum in case of the relapsing urine track system infection and the peculiarities of their antibiotic resistence in children.
3. to study the abilities of E. coli to form the film in case of children with cystitis and pyelonephritis.
4. to study the adhesive properties of E. coli in case of children’s relapsing urine track system infection
5. Taking into account the obtained data to develop the program of the anti relapsing therapy in children with UTI.
Project proposer:   Tamara Godlevskaya (Ukraine)
Partner role:  Project participant 
Partner organisation:  Research
Call for proposal title:  N/A 


Description of the collaboration sought: 
We are looking for other medical institutions and European universities with interests and experience in the fields of Public Health, management of chronic diseases to lead the project and become our partners for the Call. 
Expertise sought: Medicine. Health, 
Roles sought: Project participant, 
Organisation types sought: Research, 
Countries sought: Austria, Belgium, Bulgaria, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Luxembourg, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom, Serbia, Norway, Switzerland, Canada, Australia,