Proje Geliştirme ve
Koordinasyon Birimi

2015-10-30 Denmark: Unraveling Principles of PDZ-mediated Cell Signaling


Unraveling Principles of PDZ-mediated Cell Signaling

Description of the project offered: 
The PDZnet consortium will create a European PhD Training Network (ETN) focusing on unraveling PDZ domain-mediated signaling pathways. PDZnet got on the waiting list for a grant agreement after the H2020-MSCA-ITN-2015 call with a total score of 95%. The overall research objective of PDZnet is to explore PDZ-mediated signaling networks as a novel principle for the treatment of cancer and diseases of the nervous system such as schizophrenia, Alzheimer’s disease and depression. The majority of the current therapeutic interventions act by targeting proteins in the membrane of cells, such as receptors, transporters and ion channels. In recent years it has become increasingly evident that a complex network of intracellular signaling pathways driven by protein-protein interactions (PPIs) is activated, leading to a range of cellular responses. Fundamental mediators of PPIs are so-called PDZ (Postsynaptic density-95, Discs large 1, Zonula occludens-1) domains, which are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies. Due to the complex nature of these interactions, it has appeared exceedingly difficult to target them with potent small molecules. Instead, spin-out companies such as NoNO Inc. and Avilex Pharma have demonstrated that peptide-based inhibitors of PDZ-mediated PPIs have a large, untapped potential in brain diseases such as ischemic stroke. The multidisciplinary PDZnet platform integrates a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. At present, the PDZnet consortium encompasses 8 academic and 2 industrial partners (Denmark, France, Sweden, Italy, Germany, Portugal).

Keywords: Protein–protein interactions, protein-lipid interactions, PDZ domains, signaling, trafficking, cancer, CNS diseases, intracellular protein network, PDZ inhibitors, synaptic transmission
Project proposer:   Louise Albertsen ()
Partner role:  Project coordinator 
Partner organisation:  Education
Call for proposal title:  Marie Sklodowska-Curie Innovative Training Networks 
Call for proposal identifier:  H2020-MSCA-ITN-2016

Description of the collaboration sought: 
The PDZnet consortium is searching for a non-academic partner specialized in in vivo models of neurological disorders or cancer. The company has experience with inhibition of protein-protein interactions – preferentially, but not limited to, those mediated by PDZ domains. The partner could be a SME. As a beneficiary, the company should be able to host 1-2 PhD students and have 2-3 PhD students at secondment for 3-6 months. Finally, the partner should be highly committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. 
Expertise sought: Education. Training, Life sciences, Biotechnology, Medicine. Health, Industrial biotech, 
Roles sought: Project participant, 
Organisation types sought: Industry, Small or medium-sized enterprise (SME), Technology transfer, 
Countries sought: Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom, Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, 

Call for proposal specific information
The referenced call for proposals has no specific fields defined.