Proje Geliştirme ve
Koordinasyon Birimi

2015-09-24 Ukraine: Clinical Application of Stem Cell Based Therapy for Thymic Regeneration


2015-09-24 Ukraine: Clinical Application of Stem Cell Based Therapy for Thymic Regeneration
Description of the project offered: 
The thymus is a lympho-epithelial organ and the major site for generation of a functional self-tolerant T cell repertoire. It is thus of central importance for adaptive immune system function. The special functions of the organ are mediated primarily by the diverse array of epithelial cell types within the stroma. The thymus is also one of the first organs to degenerate in normal healthy individuals, a process termed ‘age-related thymic involution’. The function of the thymus is also suppressed under stress and a variety of cytotoxic effects, including iatrogenic (or medical treatment-related). Furthermore, partial or total thymectomy is a component of some surgical procedures, particularly neonatal surgery for congenital heart disease. Also, some forms of severe combined immunodeficiency such as DiGeorge syndrome, Nezelof syndrome, Louis-Bar syndrome, and Swiss syndrome are due to congenital thymic aplasia. Thus, lack of thymic function presents a serious problem for many patients. In our focus mainly newborn and children with congenital heart diseases whom the thymus was removed as a part of standard surgical procedure. For these patients, autologous transplantation of thymic fragments as well as thymic epithelial stem cells (TESC) can lead to successful reconstitution of immune system functions as it was showed on animal models and in some clinical investigations. In our current ThymiStem project, which runs under FP7 Health-2013 programm, we are developing TESC-basis platform for clinical intervention into thymus-deficient patients. The new proposal aim is clinical application of developed robust and validated protocols related to the cryopreservation of human thymic tissue and in vitro cultured human TESC as well as establishing of optimized means and protocols for autologous transplantation of these cells and/or thymic fragments, or thymic epithelial stem cell-based organoids to immunocompromised recipients such that thymus function is restored and immune status could be evaluated. Overall, this work will build the clinical foundations of a novel stem-cell based therapy for regenerative recovery of thymic and thus immune system functions in the patients. The project should brings together a strong team comprising stem cell biologists, immunologists, molecular biologist and heart surgeons, which are experts in immune reconstitution, tissue engineers, genomics, cryopreservation and cell banking as well as in clinical investigations.
Call for proposals: Research and innovation actions: SC1-PM-11-2016-2017 - Clinical research on regenerative medicine. Deadline - 13.04.2016
Project proposer:   Valentin Shichkin (Ukraine)
Partner role:  Project coordinator 
Partner organisation:  Education
Call for proposal title:  N/A 


Description of the collaboration sought: 
We are looking for stem cell biologists, immunologists, molecular biologist and heart surgeons, which are experts in immune reconstitution, tissue engineers, genomics, cryopreservation and cell banking as well as in clinical investigations. 
Expertise sought: Intellectual property rights, Research ethics, Scientific research, Innovation. Technology transfer, Medical biotechnology, Biotechnology, Medicine. Health, 
Roles sought: Project coordinator, Project participant, 
Organisation types sought: Education, Technology transfer, Small or medium-sized enterprise (SME), Research, 
Countries sought: Austria, Belgium, Czech Republic, Denmark, France, Germany, Finland, Italy, Netherlands, Bulgaria, Estonia, Greece, Hungary, Latvia, Lithuania, Poland, Portugal, Slovakia, Romania, Spain, Sweden, United Kingdom, Slovenia, Cyprus, Croatia, Israel, Norway, Switzerland, Turkey, Belarus, India, Australia, Armenia, Azerbaijan, China, Canada, Japan, Georgia, Moldova, Republic of, Cuba, Russian Federation, Singapore, United Arab Emirates, United States